LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase ( LDHA ) inhibitor ( IC 50 =145.2 nM). LDHA-IN-3 can be used for the research of cancer In Vitro PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect. PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage. PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells Concentration: 0~500 μM Incubation Time: 48 hours Result: Showed cytotoxic effect. Form:Solid IC50& Target:IC50: 145.2 nM (LDHA)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
LDHA-IN-3
CAS number：227010-33-5 molecular formula：C13H9F3Se
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 227010-33-5 | molecular formula | C13H9F3Se |
| molecular weight | 301.17 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
