LTV-1 is a potent lymphoid tyrosine phosphatase ( LYP ) inhibitor in T cells with an IC 50 of 508 nM. LTV-1 has the potential for autoimmunity treatment In Vitro LTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa cells, Jurkat TAg T cells, and PBMC Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM Incubation Time: 48 hours Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Form:Solid IC50& Target:IC50: 508 nM (LYP, in T cells)
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LTV-1
CAS number：347379-29-7 molecular formula：C26H20N2O5S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 347379-29-7 | molecular formula | C26H20N2O5S |
| molecular weight | 472.51 g/mol | Exact mass | ≥98% |
| PSA | 128.000 Ų | logp | 4.700 |
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