compound introduction
653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC 50 of 26.3 μM. In Vitro 653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
