SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride IC50& Target:CDK8/CycC 4.4 nM (IC 50 ) CDK19/CycC 10.4 nM (IC 50 ) CDK9/cycT 1070 nM (IC 50 ) In Vitro:SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8. SEL120-34A monohydrochloride w In Vivo:SEL120-34A monohydrochloride (30, 60mg/kg, p.o. once every day) inhibits growth of AML tumors in a dose-dependent manner in SCID mice after treatment for 17 days. MCE has not independently confirmed the accuracy of these methods. They are for refere Biological Activity:SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride
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SEL120-34A monohydrochloride
CAS number：unknown molecular formula：C15H19Br2ClN4
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| Chinese alias | SEL120-34A 单盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C15H19Br2ClN4 |
| molecular weight | 450.6 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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