Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s Appearance:Solid IC50& Target:KDM1/LSD1 In Vitro:Bomedemstat dihydrochloride selectively inhibits proliferation and induces apoptosis of Jak2 V617F cells by concomitantly increasing expression and methylation of p53. Bomedemstat (50 nM-1 μM; 96 h; SET-2 cells) dihydrochloride enhances survival, ind In Vivo:Bomedemstat (oral gavage; 45mg/kg; once daily; 56 d) dihydrochloride normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis. MCE has not independently confirmed the ac Biological Activity:Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 ( LSD1 ) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride s
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Bomedemstat dihydrochloride
CAS number：unknown molecular formula：C28H36Cl2FN7O2
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| Chinese alias | 盐酸波美司他 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C28H36Cl2FN7O2 |
| molecular weight | 592.54 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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