PCSK9-IN-11 (compound 5r) is a potent and orally active PCSK9 inhibitor. PCSK9-IN-11 exhibits PCSK9 transcriptional inhibitory activity in HepG2 cells, with an IC 50 of 5.7 μM. PCSK9-IN-11 increases LDL receptor (LDLR) protein level. PCSK9-IN-11 can be us Appearance:Solid IC50& Target:IC50: 5.7 μM (PCSK9) In Vitro:PCSK9-IN-11 (compound 5r) (0-25 μM, 24 h) significantly decreases PCSK9 protein level and increases LDLR expression in a dose dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Bl In Vivo:PCSK9-IN-11 (compound 5r) (0-1000mg/kg, IG, once) exhibits a good in vivo safety feature with the halflethal dose (LD 50 ) value of over 1000mg/kg. PCSK9-IN-11 (30mg/kg, IG, once a day for 8 weeks) significantly suppresses hepatic PCSK9 expression Biological Activity:PCSK9-IN-11 (compound 5r) is a potent and orally active PCSK9 inhibitor. PCSK9-IN-11 exhibits PCSK9 transcriptional inhibitory activity in HepG2 cells, with an IC 50 of 5.7 μM. PCSK9-IN-11 increases LDL receptor (LDLR) protein level. PCSK9-IN-11 can be us
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PCSK9-IN-11
CAS number：unknown molecular formula：C16H17ClFN5O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C16H17ClFN5O3 |
| molecular weight | 381.79 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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