compound introduction
SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a K d of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro. Appearance:Solid IC50& Target:Kd: 80 nM (chromobox 2 chromodomain) In Vitro:SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation. MCE has not independently confirmed the accuracy of these methods. They are for reference Biological Activity:SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a K d of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro.
