MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. Appearance:Solid IC50& Target:PRMT5•MTA In Vitro:MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC 50 3 nM; prolif. IC 50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC 50 544 nM; prolif. IC 50 861 nM). MRTX9768 (0-250 nM) results in LU99 SDMA inhibi In Vivo:In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow. MRTX9768 selectively targets MTAP/CDKN2A-deleted tumors (such as glioblastoma) Biological Activity:MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.
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MRTX9768 hydrochloride
CAS number：unknown molecular formula：C24H18ClFN6O
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| Chinese alias | MRTX9768 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C24H18ClFN6O |
| molecular weight | 460.89 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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