Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent. IC50& Target:IC50: 86 nM (Arginase 1), 296 nM (Arginase 2) In Vitro:Numidargistat dihydrochloride is a potent and orally-bioavailable inhibitor of arginase, with IC 50 s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively. Numidargistat dihydrochloride inhibits native rginase 1 (Arg1) in human granulocyt In Vivo:Numidargistat dihydrochloride (100mg/kg, p.o., twice per day) increases the number of tumor-infiltrating cytotoxic cells and decreases myeloid cells in mice. Numidargistat dihydrochloride in combination with PD-L1 blockade or LY 188011 inhibits tumor gro Biological Activity:Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent.
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Numidargistat dihydrochloride
CAS number：unknown molecular formula：C11H24BCl2N3O5
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| Chinese alias | 努米达司他二盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C11H24BCl2N3O5 |
| molecular weight | 360.04 g/mol | Exact mass | 10mM |
| PSA | - | logp | - |
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