compound introduction
Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of Appearance:Solid IC50& Target:DOT1L In Vitro:Dot1L-IN-1 (analogue 7) TFA effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC 50 =5 nM). MCE has not independently confirmed the accuracy of these methods. They are for Biological Activity:Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of
