TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 ( HY-151948 ). TrkA-IN-4 exhibits potent antinociceptive effects. Appearance:Solid IC50& Target:TrkA In Vitro:TrkA-IN-4 (compound 39) demonstrates 65.1% and 46.3% of kinase inhibition towards TrkA at concentrations of 1 μM and 0.1 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:TrkA-IN-4 (compound 39) (0.9375-120mg/kg; i.g.) exhibits stronger maximum antinociceptive effects 3 h after administration, with an ED 50 of 7.836mg/kg in hot plate testing on male mice. MCE has not independently confirmed the accuracy of these met Biological Activity:TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a proagent of TrkA-IN-3 ( HY-151948 ). TrkA-IN-4 exhibits potent antinociceptive effects.
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TrkA-IN-4
CAS number：unknown molecular formula：C27H21F3N4O5
overview
compound introduction
Specs
| Chinese alias | TrkA基因 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C27H21F3N4O5 |
| molecular weight | 538.47 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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