ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 ( TrxR1 ) with IC 50 s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis. Appearance:Solid IC50& Target:IC50: 50 nM (IDO1), 3.0 μM (TrxR1) In Vitro:ZC0109 (24 h) inhibits cancer cells with IC 50 s of 3.44 μM (HCT-116), 12.4 μM (CT26), and 10.2 μM (HeLa), respectively. ZC0109 (2.5-10 μM; 24 h) induces ROS accumulation in HCT-116 and HeLa cells. ZC0109 (2.5-10 μM; 24 h) induces apoptosis and In Vivo:ZC0109 (15, 30, and 60mg/kg; p.o.; once daily for 28 d) reduces Kyn/Trp metabolism in C57BL/6 mice. ZC0109 (60mg/kg; p.o.; once daily for 28 d) decreases tumor growth and increases accumulation and infiltration of T cells in CT-26 cells transplante Biological Activity:ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 ( TrxR1 ) with IC 50 s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis.
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ZC0109
CAS number：unknown molecular formula：C22H20BrFN8O4S
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C22H20BrFN8O4S |
| molecular weight | 591.41 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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