Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity . Elimusertib hydrochloride can be used for the research of solid tumors and ly IC50& Target:ATR 7 nM (IC 50 ) In Vitro:Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC 50 of 78 nM. Elimusertib hydrochloride potently suppresses hydroxyurea-induced H2AX phosphorylation (IC 50 : 36 nM) . Eli In Vivo:Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models. Elimusertib hydrochloride (50 mg/kg; p.o. Biological Activity:Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and ly
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RdRP-IN-2
CAS number：unknown molecular formula：C20H22ClN7O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C20H22ClN7O |
| molecular weight | 411.89 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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