LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC 50 of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory e Appearance:Solid IC50& Target:IC50: 0.68 μM (αvβ3 integrin) In Vitro:LXW7 specially binds to αvβ3 integrin (K d =76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imagin In Vivo:LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines. MCE has not independently confirmed the accuracy of Biological Activity:LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC 50 of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory e
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LXW7 TFA
CAS number：unknown molecular formula：C31H49F3N12O14S2
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| Chinese alias | LXW7 三氟乙酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C31H49F3N12O14S2 |
| molecular weight | 934.92 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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