compound introduction
G3-C12 is a galectin-3 binding peptide, with K d of 88 nM, and shows anticancer activity. In Vitro G3-C12 is a galectin-3 binding peptide, with high affinity (K d ) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Kd: 88 nM (Galectin-3)
