NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC 50 of 182 nM. In Vitro NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IL-2 182 nM (IC 50 )
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NFAT Transcription Factor Regulator-1
CAS number：245747-71-1(DMSO) molecular formula：C17H10F6N4O2
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| Chinese alias | NFAT 转录因子调节剂-1 | ||
| English alias | - | ||
| CAS number | 245747-71-1(DMSO) | molecular formula | C17H10F6N4O2 |
| molecular weight | 416.28 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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