CAS number：1953133-47-5 molecular formula：C27H31F5N4O
Giredestrant (GDC-9545) 是一种新型 ER 拮抗剂，结合了理想的机制和临床前 DMPK 属性。Giredestrant 的高效体内功效可能是由于其具有高 ER 结合力、ER 信号传导的完全抑制和改善的 DMPK 特征。 Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity
| Chinese alias | 吉雷德斯特兰 | ||
| English alias | Giredestrant [USAN] | NSC827275 | NSC-827275 | AKOS040733254 | FLUCICLOVINE (18F) [WHO-DD] | AC-37111 | GDC9545 | GDC-9545 | MS-29682 | AFIMOXIFENE, Z-ISOMER | EX-A3541 | 5AzadC | AT22918 | 3-((1R,3R)-1-(2,6-Difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)am | ||
| CAS number | 1953133-47-5 | molecular formula | C27H31F5N4O |
| molecular weight | 522.55 g/mol | Exact mass | ≥98% |
| PSA | 54.500 Ų | logp | 4.8 |
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