NMDAR/TRPM4-IN-2 (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 shows neuroprotective activity. NMDAR/TRPM4-IN-2 prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC 50 of 2.1 μM. NMDAR/TRPM4-IN-2 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. In Vitro NMDAR/TRPM4-IN-2 (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner. NMDAR/TRPM4-IN-2 eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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NMDAR/TRPM4-IN-2
CAS number：2243506-33-2 molecular formula：C11H19BrCl2N2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2243506-33-2 | molecular formula | C11H19BrCl2N2 |
| molecular weight | 330.09 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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