NRX-2663 is an enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC 50 of 22.9 µM and a K d of 54.8 nM In Vitro NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC 50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 22.9 µM (β-catenin:β-TrCP Interaction), Kd: 54.8 nM (β-catenin:β-TrCP Interaction)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
NRX-2663
CAS number：2763260-34-8 molecular formula：C20H13F3N2O5
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2763260-34-8 | molecular formula | C20H13F3N2O5 |
| molecular weight | 418.32 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
