Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin , involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis , leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60 , a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex. In Vitro Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin-mutated HCT116 cells and isogenic HCT116 (CTNNB1 Δ45/-) cells, and induces (10 μM; 24 h) apoptosis in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–) Concentration: 0, 5, 8, 10, 12, and 15 μM Incubation Time: 48 hours Result: Inhibited cell growth with inhibition rate of 100% at 15 μM. Form:Solid
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Miclxin
CAS number：2494198-61-5 molecular formula：C26H27N5O2
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| Chinese alias | 米克信 | ||
| English alias | - | ||
| CAS number | 2494198-61-5 | molecular formula | C26H27N5O2 |
| molecular weight | 441.52 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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