ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK . ASN007 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ASN007 benzenesulfonate can be used for the research of cancers driven by RAS mutations In Vitro ASN007 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ASN007 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:ERK1 ERK2
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ASN007 benzenesulfonate
CAS number：2055597-39-0 molecular formula：C28H31ClFN7O5S
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| Chinese alias | ASN007 苯磺酸盐 | ||
| English alias | - | ||
| CAS number | 2055597-39-0 | molecular formula | C28H31ClFN7O5S |
| molecular weight | 632.11 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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