Foxy-5 TFA 是 WNT5A 激动剂，是 WNT5A 的一个模拟肽，是 Wnt 家族的非经典成员。Foxy-5 TFA 可在不影响 β-catenin 激活的情况下触发胞浆游离钙信号传导，并可抑制上皮癌细胞的迁移和侵袭。Foxy-5 TFA 在原位小鼠模型中能有效降低 WNT5A 低表达的前列腺癌细胞的转移扩散。 Sequence：{For}-Met-Asp-Gly-Cys-Glu-Leu Appearance:Solid IC50& Target:WNT5A In Vivo:Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer. MCE has not independentl Biological Activity:Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithe
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Foxy-5 TFA
CAS number：881188-51-8(free base) molecular formula：C28H43F3N6O14S2
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| Chinese alias | - | ||
| English alias | L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl- (TFA) | ||
| CAS number | 881188-51-8(free base) | molecular formula | C28H43F3N6O14S2 |
| molecular weight | 808.80 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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