HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM; ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis. Appearance:Solid IC50& Target:IC50: 27.8 nM (STAT3 luciferase activity) In Vitro:HP590 (0-40 μM; 72 h) shows anti-proliferative activities to MKN45, AGS, and MGC803 cells. HP590 (0-40 nM; 0-24 h) inhibits STAT3 Tyr 705 and Ser 727 phosphorylation in GC cells, blocks the expression of STAT3 downstream genes (c-Myc and cyclin D1) i In Vivo:HP590 (oral administration; 25 and 50mg/kg; once daily; 5 w) inhibits GC growth effectively by inhibiting the STAT3 activation and shows better tolerance in GC xenograft model. MCE has not independently confirmed the accuracy of these methods. They Biological Activity:HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM; ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
HP590
CAS number：unknown molecular formula：C29H24F6N4O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C29H24F6N4O3 |
| molecular weight | 590.52 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
