STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer- Appearance:Solid IC50& Target:STAT3 In Vitro:STAT3-IN-12 (compound 24, 0-10 μM approximately, 72 h) inhibits cancer cell growth and migration in HepG2 and EC109 cells. STAT3-IN-12 (0-20 μM, 16 h) binds to the STAT3 protein and inhibits IL-6-mediated STAT3 phosphorylation, also inhibts STAT3 nuc In Vivo:STAT3-IN-12 (compound 24, intraperitoneal injection, 20, 40mg/kg, daily for 24 days) displays obvious antitumor activity in a mouse HepG2 cell xenograft tumor model without no obvious toxicity. MCE has not independently confirmed the accuracy of the Biological Activity:STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-
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STAT3-IN-12
CAS number：unknown molecular formula：C28H30N4O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C28H30N4O2 |
| molecular weight | 454.56 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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