compound introduction
PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC 50 values of 0.51, 13.2 and 14.1 µM against HEK NaCT , HEK NaDC1 and HEK NaDC3 , respectively In Vitro PF-06761281 (Compound 4a) inhibits citrate uptake with IC 50 values of 0.12, 0.21 and 0.74 µM in rat, mouse and human Heps. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC 50 : 0.51 µM (HEK NaCT ), 13.2 µM (HEK NaDC1 ), 14.1 µM (HEK NaDC3 )
