compound introduction
AS-85 is a potent ASH1L histone methyltransferase inhibitor ( IC 50 =0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K d value of 0.78 µM. In Vitro AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI 50 values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
