BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels In Vivo BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus . BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t 1/2 s of 31 hours and 33 hours for iv and po. And the C max s are 0.28 kg/L and 0.066 kg/L for iv and po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intact female rats Dosage: 4.5, 9, 18, 36, 72 mg/kg Administration: Oral; for 8 days Result: Dosedependently lowered serum estradiol levels in proestrus. Animal Model: Female and male Wistar rats Dosage: 0.5 mg/kg of iv or 2 mg/kg of po Administration: Iv or po Result: Has t 1/2 s of 31 hours and 33 hours for iv and po. And the C max s are 0.28 kg/L and 0.066 kg/L for iv and po. Form:Solid IC50& Target:IC50: 185 nM (hLH), 46nM (rLH) and 78 nM (cLH)
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BAY-298
CAS number：2471978-97-7 molecular formula：C27H21ClFN3O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2471978-97-7 | molecular formula | C27H21ClFN3O2 |
| molecular weight | 473.93 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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