Z-VAD-FMK是ICE-样蛋白酶（Caspase）的抑制剂。在THP.1细胞中，Z-VAD-FMK可以抑制不同刺激诱导的凋亡。在Jurkat T细胞中，它可以抑制Fas抗原诱导的凋亡。Z-VAD-FMK通过阻断proCPP32活化，而非阻止CPP32的蛋白水解活性从而抑制细胞凋亡。 Z-VAD-FMK抑制不同刺激诱导下的大的DNA片段的形成，且几乎可以完全抑制所有四个刺激诱导下的大的DNA片段的形成。在TLCK存在时，Z-VAD-FMK也可以完全抑制由thapsigargin或cycloheximide诱导的大DNA片段的增加，这与Z-VAD-FMK能够抑制这些处理诱导的凋亡是一致的。这些结果表明Caspase作用于大的DNA片段形成之前的阶段。 Z-VAD-FMK对STS诱导的细胞坏死几乎没有效果，表明Caspase不参与细胞坏死的发生。 序列 Z-Val-Ala-Asp(OMe)-FMK。 Product Application： Z-VAD-FMK has been used: to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells to induce autophagy in Jurkat and K562 cells to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53
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Z-VAD(OMe)-FMK
CAS number：187389-52-2 molecular formula：C22H30FN3O7
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| Chinese alias | - | ||
| English alias | (5-aminobenzo[a]phenoxazin-9-ylidene)-diethylazanium;chloride | Bio2_000951 | NCGC00163487-02 | 2-(N(omega)-L-arginine)succinic acid | benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone | benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone | Benzy | ||
| CAS number | 187389-52-2 | molecular formula | C22H30FN3O7 |
| molecular weight | 467.49 g/mol | Exact mass | ≥98% |
| PSA | 140.000 Ų | logp | 1.900 |
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