Dabigatran ethyl ester hydrochloride

CAS number：211914-50-0(DMSO) molecular formula：C27H30ClN7O3

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overview

compound introduction

Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase ( NQO2 ) with an IC 50 value of 0.8 μM and a thrombin inhibitor. In Vitro The K i of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC 50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Dabigatran (K i =4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.8 μM (NQO2)

Specs

Chinese alias	达比加群乙酯盐酸盐
English alias	-
CAS number	211914-50-0(DMSO)	molecular formula	C27H30ClN7O3
molecular weight	536.04 g/mol	Exact mass	10mM in DMSO
PSA	-	logp	-

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Safety information

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GHS07

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Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移