Meloxicam 钠盐水合物已被证明可消除胸腺素诱导的大鼠肝脏中细胞因子和NGF的增加,并抑制肿瘤生长。Meloxicam 可能能够拮抗恶病质。Meloxicam 是一种非甾体抗炎药(NSAID),相对于Cox-1(cyclooxygenase-1)抑制作用,其对Cox-2(cyclooxygenase-2)的抑制作用具有300倍的选择性。 Meloxicam sodium salt hydrate has been shown to abolish thymulin-induced increases of cytokines and NGF in the liver of rats and displays tumor growth suppression. Meloxicam may be capable of antagonizing cachexia|in vitro|. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that shows 300-fold selectivity for Cox-2 (cyclooxygenase-2) inhibition versus Cox-1(cyclooxygenase-1) inhibition.
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sodium 2-methyl-3-[(5-methyl-1,3-thiazol-2-yl)carbamoyl]-1,1-dioxo-1lambda6,2-benzothiazin-4-olate
Dangerous GoodsCAS number:71125-39-8 molecular formula:C14H12N3NaO4S2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 71125-39-8 | molecular formula | C14H12N3NaO4S2 |
| molecular weight | 373.4 | Exact mass | - |
| PSA | 139 | logp | - |
numbering system
| CAS | 71125-39-8 |
| ChEMBL ID | CHEMBL1256873 |
| PubChem CID | 4051 |
| DSSTox Substance ID | DTXSID601017452 |
| PubChem Reference Collection SID | 500799848 |
physicochemical properties
| 复杂性 | 634 |
| 溶解度 | >56 [ug/mL] (pH 7.4时结果的平均值) |
| Exact Mass | 373.01669250 |
| 形式电荷 | 0 |
| 重原子计数 | 24 |
| Molecular Weight | 373.4 |
| Monoisotopic Mass | 373.01669250 |
| 可旋转键计数 | 2 |
| 氢键供体计数 | 1 |
| 氢键受体计数 | 7 |
| 共价键单元计数 | 2 |
| 同位素原子计数 | 0 |
| 拓扑极性表面积 | 139 Ų |
| Collision Cross Section | 174.5 Ų [M+H]+ [CCS 类型:TW;方法:用聚丙氨酸和药物标准品校准] |
| 定义键立体中心计数 | 0 |
| 定义原子立体中心计数 | 0 |
| 未定义键立体中心计数 | 0 |
| 未定义原子手性中心计数 | 0 |
Safety information
WGK Germany:
3
Production methods and uses
purpose
工业应用参考:
工业分类参考:医药制造业。
应用场景参考:在环境监测、水资源分析、矿产检测、农残筛查和大气污染研究等方向具备潜在应用空间 。
作用参考:可用于改善产品性能、稳定性或使用体验,在配方优化和质量提升中具备辅助价值 。
选型提示:不同品牌和不同标准体系下的技术参数可能存在差异,应用前应优先核对规格、检测方法和质量要求 。
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