已发现细胞渗透性抗生素香豆霉素A | 1 |是能够激活修饰的Raf-1蛋白并刺激丝裂原激活的蛋白激酶级联反应的二聚剂。还已经报道该化合物诱导GyrB-Janus激酶（JAK）2融合蛋白的自磷酸化，从而绕过受体活化。JAK是与细胞因子受体的胞内结构域相互作用的细胞质蛋白激酶，其在信号转导中起重要作用。JAK的活化被认为诱导细胞增殖。研究表明，香豆霉素A | 1 |可以通过与回旋酶B亚基结合来抑制回旋酶的超螺旋活性。 Coumermycin A|1|, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A|1|can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.
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Coumermycin A₁
Dangerous GoodsCAS number：4434-05-3 molecular formula：C55H59N5O20
overview
compound introduction
Specs
| Chinese alias | 香豆霉素 A₁ | ||
| English alias | Coumermycin [USAN] | Cumamicina | HY-N7452 | [(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-4-methyl-1H-pyr | ||
| CAS number | 4434-05-3 | molecular formula | C55H59N5O20 |
| molecular weight | 1110.08 g/mol | Exact mass | - |
| PSA | 347.000 Ų | logp | 4.600 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
RTECS：
UX9375000
Production methods and uses
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downstream information
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MSDS
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