CAS number：475108-18-0 molecular formula：C22H19ClN4O5
Tivozanib (AV-951)是VEGFR抑制剂，对VEGFR1，2和3的IC50分别为30 nM，6.5 nM和15 nM，还能抑制PDGFR和c-Kit，对FGFR-1，Flt3，c-Met，EGFR和IGF-1R的抑制性较低。 Tivozanib (AV-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R.
| Chinese alias | - | ||
| English alias | NSC800952 | NSC-800952 | Tivozanib (AV-951) | AKOS022177607 | HMS3745C05 | BCP01980 | GTPL6058 | SATAVAPTAN [MART.] | .ALPHA.-ARBUTIN | 172030934T | HMS3265A11 | 1-(2-CHLORO-4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY)PHENYL)-3-(5-METHYLISOXAZOL-3-YL)UREA | NCGC0024 | ||
| CAS number | 475108-18-0 | molecular formula | C22H19ClN4O5 |
| molecular weight | 454.87 g/mol | Exact mass | ≥98% |
| PSA | 108.000 Ų | logp | 4 |
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