CAS number：1144068-46-1 molecular formula：C27H33N7O4
WYE-125132是ATP竞争性mTOR选择性抑制剂，IC50为0.19 nM，对PI3Ks及其相关的hSMG1和ATR抑制性较弱。A highly potent, ATP-competitive, and specific mTOR kinase inhibitor WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR. A highly potent, ATP-competitive, and specific mTOR kinase inhibitor
| Chinese alias | N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]-N'-甲基脲 | ||
| English alias | EX-A2183 | WYE125132 | WYE-125132 | 3-(4-methoxyphenyl)-1-methyl-5-p-tolyl-1H-pyrazole | NCGC00346635-01 | Q27163233 | B0561 | CHEBI:91364 | Heveacrumb SMR 5L | SB19261 | Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H | ||
| CAS number | 1144068-46-1 | molecular formula | C27H33N7O4 |
| molecular weight | 519.61 g/mol | Exact mass | ≥98% |
| PSA | 116.000 Ų | logp | 2.2 |
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