CAS number：761439-42-3 molecular formula：C30H40ClN7O3S
TAE684 (NVP-TAE684)是一种有效的，选择性的ALK抑制剂，IC50为3 nM，作用于ALK比作用于InsR选择性高100倍。A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 Kinase TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM, 100-fold more sensitive for ALK than InsR. A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 Kinase
| Chinese alias | - | ||
| English alias | 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-pyperidinyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine | 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine | AB08754 | ||
| CAS number | 761439-42-3 | molecular formula | C30H40ClN7O3S |
| molecular weight | 614.2 g/mol | Exact mass | - |
| PSA | 111.000 Ų | logp | 5.700 |
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