CAS number：950769-58-1 molecular formula：C29H32N6O4S
Quizartinib (AC220)是一种二代FLT3抑制剂，作用于Flt3(ITD/WT)，IC50为1.1 nM/4.2 nM，作用于Flt3比作用于KIT， PDGFRA， PDGFRB， RET，和CSF-1R选择性高10倍。Phase 3。An Flt-3/Flk-2 inhibitor. Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 3. An Flt-3/Flk-2 inhibitor.
| Chinese alias | - | ||
| English alias | NCGC00242493-02 | N-(5-tert-Butylisoxazol-3-yl)-N'-[4-[7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea | NCI60_041312 | quizartinibum | AC220 | AC-220 | SMR004703000 | vanflyta | SCHEMBL72923 | CVWXJKQAOSCOAB-UHFFFAOYSA-N | Ur | ||
| CAS number | 950769-58-1 | molecular formula | C29H32N6O4S |
| molecular weight | 560.68 g/mol | Exact mass | - |
| PSA | 134.000 Ų | logp | 5.600 |
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