Fedratinib (SAR302503, TG101348)

Dangerous Goods

CAS number：936091-26-8 molecular formula：C27H36N6O3S

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physicochemical properties

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MSDS

overview

compound introduction

TG-101348 (SAR302503)是JAK2选择性抑制剂，IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍，同时还能抑制BRD4，IC50为340 nM。A selective inhibitor of JAK2 tyrosine kinase TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3, TG-101348 also inhibit BRD4 with IC50 of 340 nM. A selective inhibitor of JAK2 tyrosine kinase

Specs

Chinese alias	费德拉替尼(SAR302503、TG101348)
English alias	7.ALPHA.-METHYLNORETHINDRONE \| FEDRATINIB [WHO-DD] \| NSC800099 \| NSC-800099 \| N-Tert-butyl-3-(5-methyl-2-(4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino)-pyrimidin-4-ylamino)-benzenesulfonamide \| Fedratinib (TG101348) \| 936091-26-8 (free base) \| s2736 \| Z203728
CAS number	936091-26-8	molecular formula	C27H36N6O3S
molecular weight	524.68 g/mol	Exact mass	-
PSA	117.000 Å²	logp	4.8

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Safety information

pictogram：

GHS08 , GHS07

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Warning

Hazard Statement：

H302: 吞食有害 H361d: 怀疑损害胎儿

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。