HSP-990是具有潜在抗肿瘤活性的人类热休克蛋白90（Hsp90）的抑制剂。Hsp-990结合并抑制Hsp90的活性，这可能导致致癌的客体蛋白（包括HER2 / ERBB2）的蛋白酶体降解以及对肿瘤细胞增殖的抑制。Hsp90是在多种肿瘤细胞中上调的分子伴侣，它在致癌信号蛋白（例如HER2 / ERBB2，AKT，RAF1，BCR-ABL和突变的p53）的构象成熟，稳定性和功能中发挥关键作用，以及许多其他在细胞周期调节和/或免疫反应中很重要的分子。 HSP-990 is an inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp-990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.
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HSP-990
CAS number：934343-74-5 molecular formula：C20H18FN5O2
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one | UNII-E0WBA7B62L | s7097 | HSP990 (NVP-HSP990) | HY-15190 | NVP-HSP990 (HSP990) | E0WBA7B62L | Magnesium carbonate [USAN] | BCP9001013 | HSP 99 | ||
| CAS number | 934343-74-5 | molecular formula | C20H18FN5O2 |
| molecular weight | 379.39 g/mol | Exact mass | ≥98% |
| PSA | 103.000 Ų | logp | 2.100 |
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