储存在-20℃。存放在干燥的条件下。该产品最多可存储12个月。 Description UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of Application In MDA-MB-231 cells, in a concentration-dependent manner, exposure to UNC0638 for 48 h reduced H3K9me2 levels with an IC50 value of 81 ± 9 nM. Cellular levels of H3K9me2 were progressively reduced from 1 d to 4 d exposure to UNC0638 at the concentrations of 80 nM (IC50), 250 nM (IC90) and 500 nM (2 × IC90). The reductions of H3K9me2 levels with 250 nM and 500 nM treatments after 4 d were equal or very close to that of G9a and GLP knockdown cells. The effects of UNC0638 were long-lasting. In cells with 2 d exposure to UNC0638, levels of H3K9me2 remained low after washout of compound followed by 2 d incubation without the inhibitor.
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UNC0638
CAS number：1255580-76-7 molecular formula：C30H47N5O2
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| Chinese alias | - | ||
| English alias | AC-32711 | AS-74910 | CCG-208706 | J-509244 | SB19045 | DTXSID30154787 | NSC764517 | NSC-764517 | 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine | NCGC00189220-05 | SCHEMBL14844528 | 26A103L2FO | | ||
| CAS number | 1255580-76-7 | molecular formula | C30H47N5O2 |
| molecular weight | 509.73 g/mol | Exact mass | - |
| PSA | 62.800 Ų | logp | 6.300 |
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