Brivanib (BMS-540215)

Dangerous Goods

CAS number：649735-46-6 molecular formula：C19H19FN4O3

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Brivanib (BMS-540215)是一种ATP竞争性的VEGFR2抑制剂，IC50为25 nM，对VEGFR-1和FGFR-1抑制作用适中，但比作用于PDGFR-β效果强240多倍。An ATP-competitive inhibitor against VEGFR-2, Flk-1, VEGFR-1 and FGFR-1 Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. An ATP-competitive inhibitor against VEGFR-2, Flk-1, VEGFR-1 and FGFR-1

Specs

Chinese alias	酪氨酸激酶抑制剂 \| 布立尼布
English alias	Brivanib \| BRIVANIB [MI] \| EX-A011 \| A24076 \| BMS540215 \| BMS-540215 \| Brivanib [USAN] \| CCG-268296 \| SMR004703038 \| NCGC00263160-01 \| MFCD13194684 \| s1084 \| Brivanib (USAN) \| DL-1,2-Diphenyl-1,2-ethanediol \| UNII-DDU33B674I \| Brivanib (BMS-540215) \| GTPL
CAS number	649735-46-6	molecular formula	C19H19FN4O3
molecular weight	370.39 g/mol	Exact mass	-
PSA	84.700 Å²	logp	3

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS08

Signal word：

Danger

Hazard Statement：

H373: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。