Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
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5-Aza-2′-deoxycytidine
Dangerous GoodsCAS number：2353-33-5 molecular formula：C8H12N4O4
overview
compound introduction
Specs
| Chinese alias | 5-氮杂-2'-脱氧胞苷 | 5-氮杂-1-(2-脱氧-β-D-呋喃核糖基)胞嘧啶 | 地西他滨 2'-脱氧-5-氮杂胞苷 | 4-氨基-1-(2-脱氧-β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)- 酮 | ||
| English alias | 2-deoxyazacytidine | 5-Aza-2'-deoxycytidine, >=97% | 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one | 2'-desoxy-5-azacytidine | 2-Desoxy-5-azacytidine | E-7373 | MLS006010136 | NSC127716 | NSC-127716 | DECITABINE (MART.) | DECITABIN | ||
| CAS number | 2353-33-5 | molecular formula | C8H12N4O4 |
| molecular weight | 228.21 g/mol | Exact mass | - |
| PSA | 121.000 Ų | logp | -1.2 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H341: 怀疑引起遗传缺陷 H302: 吞食有害 H360: 可能损害生育力或未出生的孩子
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P281: 根据需要使用个人防护设备。 P271: 仅在室外或通风良好的地方使用。
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US), Eyeshields, Gloves
RTECS：
XZ3012000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
2353-33-5 | Decitabine.pdf
