Ferric sulfate

SKIN: flush with water. (USCG, 1999)

...A brief exposure (1 hr) of 51Cr-radiolabeled breast cancer cells (BT-20) but not colon cancer cells (Caco-2) to hemin (10 uM) or FeSO4 (10 uM) significantly enhances cytotoxicity mediated by 0.5 mM hydrogen peroxide (H2O2). Associated with Caco-2 resistance, these cells were found to be enriched in the endogenous iron chelator, ferritin. If cellular ferritin is even further increased through 1 hr incubation (24 hr prior to H2O2 exposure) of both cell types with hemin, FeSO4, or exogenous spleen apoferritin itself (24 hr), marked resistance to H2O2-mediated cytotoxicity is manifest. Under several conditions, the sensitivity of tumor cells to oxidant-mediated lysis is inversely proportional to their ferritin content. Pretreatment of BT-20 and Caco-2 cells with hemin or FeSO4 rapidly in...

Not flammable

Inhalation of dust irritates nose and throat. Ingestion causes irritation of mouth and stomach. Dust irritates eyes and can irritate skin on prolonged contact. (USCG, 1999)

Vacated 1989 OSHA PEL TWA 1 mg/cu m is still enforced in some states. /Iron salts, soluble, as Fe/

Salts, Acidic

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Environmental considerations, water spill: Neutralize with agricultural lime, crushed limestone, or sodium bicarbonate. Adjust pH to neutral (pH= 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Pesticide Ecotoxicity Data from EPA: 22

A skin, eye, and mucous membrane irritant; Overexposure may cause liver damage; A skin, eye, and throat irritant; An irritant; [MSDSonline] See Iron salts, soluble.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. All substances listed may be in anhydrous or hydrated form. Iron sulfate is included on this list. /Iron Sulfate/

LC50 Salmo trutta (Brown trout) 47 mg total Fe/L (0.24 mg soluble Fe/L)/96 hr /Conditions of bioassay not specified in source examined/ /Analar grade iron (III) sulphate/

Residues of ferric sulfate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

FERRIC SULFATE is acidic. Corrosive to copper, copper alloys, mild steel, and galvanized steel (USCG, 1999).

Keep well closed and protected from light.

All ... /iron/ preparations should be kept in child-proof bottles. /Iron preparations/

Residues of ferric sulfate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

/AQUATIC SPECIES/ ...The acute and chronic effects upon Daphnia longispina, the dominant member of the zooplankton. Laboratory tests established that, although dissolved iron had no measurable effect, the presence of particulate iron caused mortalities in acute tests (48 hours) and reduced number of broods per female and numbers of young hatching in chronic tests (21 days). At 11.48 mg Fe/L, 50% mortalities occurred in the population, /while/ 4.49 mg Fe/L caused reductions in reproduction and increased mortality rates over 21 day tests. In inert china clay, similar results were observed, suggesting that it was the particulate nature of the ferric sulfate that caused the effects, rather than any toxic properties. A safe level of 1.69 mg Fe/L was calculated. The area of the filter of the...

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Iron salts (soluble, as Fe)/

Soluble in water. Hygroscopic in air. Forms acidic aqueous solutions.

/HUMAN EXPOSURE STUDIES/ Twenty normal and 18 asthmatic human volunteers were exposed to ferric sulfate aerosol at a nominal concentration of 75 ug/cu m (equivalent to 20 ug iron/cu m). The concentration and particle size distribution (2 micron mass median aerodynamic diameter; geometric standard deviation of 3) were selected to simulate worst case ambient conditions. Ferric sulfate was chosen for study because it is toxic, it is a respiratory system irritant, and increased use of coal and high sulfur fuel oils will lead to increased concentrations of iron and sulfate in ambient air. A double blind protocol was followed in which each subject was exposed on two days, separated by about a three week period. The subjects were exposed to clean air (sham) on one day and to ferric sulfate aer...

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)

Chemical Assessment: IMAP assessments - Sulfuric acid, iron(3+) salt (3:2): Environment tier I assessment

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ ...Standardized osseous defects were created bilaterally in the naturally edentulous zone in rabbit mandibles. The control site was sutured immediately after clot formation in the defect. The contralateral experimental site received ferric sulfate application until complete hemostasis was achieved. The defect was filled with ferric sulfate solution to maximize any effect on healing and then closed with sutures. The experimental and control specimens were examined histologically after 18 and 46 days and scored for healing. Statistical analysis by Wilcoxon signed rank test showed significant adverse effects on osseous healing when ferric sulfate solution was left in situ.

...There is concern that the individual with metabolic defects that impair the ability to regulate iron absorption will be at risk from excessive exposure to iron, primarily as a result of acceleration of accumulation of iron in the body and an earlier onset of clinical symptoms of the disease. /Iron salts/

Acute Tox. 4 (100%)

49 638 27; Ferric sulfate

Hemodialysis and hemoperfusion are not effective for removing iron but may be necessary to remove iron-deferoxamine complex in patients with renal failure. Exchange transfusion is occasionally used for massive pediatric ingestions but is of questionable efficacy.

PAC-3: 36 [mg/m3]

EPA 300 ug/L /Iron/

/NIOSH certified respirator/; goggles or face shield.

If inhaled, iron is a local irritant to the lung and gastrointestinal tract. /Iron compounds/

Australia (1978); Belgium (1978); Finland (1975); Italy (1978); Netherlands (1978); and Switzerland (1978): 1 mg/cu m. /From table/ /Ferric salts, as Fe/