compound introduction
Davercin是第一代半合成红霉素。Davercin是通过将11-和12-OH基团偶联形成环状碳酸酯而制备的。这种简单的修饰提高了大环结构的稳定性和疏水性。与红霉素相比，达弗霉素显示出相当或更好的体外效力，较低的宿主毒性和改善的药代动力学。 Davercin (Erythromycin Cyclocarbonate) 是 Erythromycin 的衍生物，对革兰氏阳性菌和一些革兰氏阴性菌都具有作用活性。 Davercin is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.
