CAS number：475207-59-1 molecular formula：C21H16ClF3N4O3·C7H8O3S
Sorafenib Tosylate是酪氨酸激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂，同时作用于Raf-1，wtBRAF和V599EBRAF，IC50分别为6 nM， 22 nM和38 nM。An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases. Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.
| Chinese alias | 甲苯磺酸索拉非尼 | ||
| English alias | CAS-475207-59-1 | methoprene-(s) | orafenib tosylate | SR-01000597705 | SW202562-3 | 4-{4-[3-(4-Cl-3-trifluoromethyl-phenyl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide 4-methylbenzenesulfonate | Sorafenib (Nexavar) | Sorafenib (Tosylate) | So | ||
| CAS number | 475207-59-1 | molecular formula | C21H16ClF3N4O3·C7H8O3S |
| molecular weight | 637.03 g/mol | Exact mass | ≥99% |
| PSA | 155.000 Ų | logp | - |
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