选择性RNA聚合酶II抑制剂； α-Amanitin 是几种致命毒蘑菇的主要毒素，通过抑制RNA 聚合酶 II (RNA-polymerase II) 发挥其毒性作用 Product Describtion: A selective RNA polymerase II inhibitor； Alpha-amanitin is the main toxin of several deadly poisonous mushrooms, exerting its toxic effects by inhibiting RNA polymerase II α-Amanitin is the major toxic bicyclic octapeptide of the Amanita phalloides mushroom that has been used in biochemical research for decades. This toxin is synthesized as a proprotein, on ribosomes, 34 to 35 amino acids in length and then cleaved at specific proline residues by an enzyme belonging to the prolyl oligopeptidase (POP) subfamily. α-Amanitin shows remarkable binding affinity for eukaryotic RNA polymerase II, slightly binds to RNA polymerase III, and shows no activity on RNA polymerase I; it has been used to determine which types of RNA polymerase are present in a given sample. The toxin works by binding to the bridging helix of RNA polymerase II inhibiting the translocation of RNA and DNA needed to empty the site for the next round of synthesis; thereby slowing the rate of transcription by over 1000 fold. α-Amanitin is an inhibitor of Pol III. A specific and potent inhibitor of eukaryotic RNA pol II and a mild inhibitor of RNA pol III.
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α-Amanitin
Dangerous GoodsCAS number：23109-05-9 molecular formula：C39H54N10O14S
overview
compound introduction
Specs
| Chinese alias | alpha-毒伞肽 | alpha-鹅膏覃碱 | ||
| English alias | Bio1_001196 | Bio1_000707 | Bio1_000218 | alpha-Amanitin, from Amanita phalloides, >=90% (HPLC), powder | 2-[(2,3-dihydroxy-1-methyl-propyl)-dihydroxy-nonaoxo-sec-butyl-[?]yl]acetamide | BCBcMAP01_000054 | CBiol_001932 | alpha-amanitin | Amanitin | SCHEMB | ||
| CAS number | 23109-05-9 | molecular formula | C39H54N10O14S |
| molecular weight | 918.97 g/mol | Exact mass | - |
| PSA | 400.000 Ų | logp | -4.400 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS08
Signal word：
Danger
Hazard Statement：
H373: 通过长时间或反复暴露对器官造成损害 H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS：
BD6195000
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
