一种多胺生物合成天然副产物，作为甲硫腺苷磷酸化酶（MTAP）的内源性底物。蛋白羧甲基转移酶的细胞渗透性，可逆性和ATP竞争性抑制剂，可诱导白血病U937细胞凋亡。还充当PC12细胞中NGF诱导的酪氨酸磷酸化的抑制剂，并阻断星形胶质细胞和胶质瘤细胞中的FGF-2受体酪氨酸激酶。 一种细胞可渗透、可逆和ATP竞争性的多胺生物合成天然副产物，作为甲硫腺苷磷酸化酶（MTAP）的内源性底物。在白血病U937细胞中有效抑制蛋白羧甲基转移酶并诱导凋亡。还抑制FGF-2受体酪氨酸激酶活性以及人星形胶质细胞和胶质瘤细胞的增殖。 A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells. A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
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5′-Deoxy-5′-(methylthio)adenosine
Dangerous GoodsCAS number：2457-80-9 molecular formula：C11H15N5O3S
overview
compound introduction
Specs
| Chinese alias | 甲硫腺苷 | (2R,3R,4S,5S)-2-(6-氨基-9H-嘌呤-9-基)-5-[(甲基硫代)甲基]四氢呋喃-3,4-二醇 | 5'-(甲基硫代)腺苷; 5′-脱氧-5′-甲基硫代腺苷 | ||
| English alias | Vitamin L2 | MFCD00010533 | 5'-(Methylthio)adenosine | 9-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-9H-purin-6-amine | (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | 5'-DEOXY-5'-METHYLTHIOADENOSINE | 5'-Deoxy-5'-methylthio-ad | ||
| CAS number | 2457-80-9 | molecular formula | C11H15N5O3S |
| molecular weight | 297.33 g/mol | Exact mass | ≥95% |
| PSA | 145.000 Ų | logp | -0.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
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upstream information
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downstream information
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MSDS
Found 1 shareMSDS
2457-80-9 | 5 ′ -Deoxy-5 ′ -adenosine | 5 ′ -Deoxy-5 ′ - (methylthio) adenosine
