compound introduction
阿齐达芬尼科尔是一种半合成的氯霉素，其中的硝基部分被甲基砜取代，二氯乙酰胺被叠氮基乙酰胺取代，该化合物于1959年在拜耳公司首先合成。阿达芬尼醇通过与50S核糖体的23S亚基结合而起作用，从而抑制蛋白质的合成。阿齐达芬尼醇几乎没有受到研究关注，仅引用了少量文献。 Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.
