1,10-Decanediol 是一种二醇类化合物，可用于与 α-酮戊二酸 (aKG) 反应，生成二醇基聚合微粒 (称为 paKG MPs)，来持续释放 aKG，从而促进免疫抑制调节。此外，paKG MPs 可与树突状细胞 (DCs) 结合，来减少其体外的糖酵解和线粒体呼吸，这些代谢变化会导致 DCs 中 MHC-II 和 CD86 表达调节，并改变体外调节性 T 细胞 (Tregs) 以及辅助性 T 细胞 1/2/17 型的频率。1,10-Decanediol 可用于免疫代谢领域领域的研究。 1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism.
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1,10-Decanediol
Dangerous GoodsCAS number：112-47-0 molecular formula：C10H22O2
overview
compound introduction
Specs
| Chinese alias | 十次甲基二醇 | 十亚甲基二醇 | 1,10-二羟基癸烷 | 亚癸基二醇 | ||
| English alias | Decamethylene glycol | 1,10-Dihydroxydecane | ||
| CAS number | 112-47-0 | molecular formula | C10H22O2 |
| molecular weight | 174.28 g/mol | Exact mass | - |
| PSA | 40.500 Ų | logp | 2.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
WGK Germany：
1
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
HD8433713
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
112-47-0 | 1,10-Decanediol.pdf
