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N-p-Tosyl-L-phenylalanine chloromethyl ketone(TPCK)

Dangerous Goods

CAS number:402-71-1    molecular formula:C17H18ClNO3S

overview

compound introduction

不可逆的丝氨酸蛋白酶抑制剂,抑制胰蛋白酶样丝氨酸蛋白酶,包括菠萝蛋白酶,糜蛋白酶,无花果蛋白酶及木瓜蛋白酶。工作液稳定期为几个小时,贮存液(10mM甲醇溶液)在4°C下可保持稳定几个月。某些丝氨酸蛋白酶的不可逆抑制剂,用于在制备胰蛋白酶时抑制胰凝乳蛋白酶。 N-p-Tosyl-L-phenylalanine chloromethyl ketone has been used: to investigate whether transcription factor NFκB is involved in renalase expression to test the role of NF-κB activation to study its inhibitory effect on chymotrypsin

Specs

Chinese alias甲苯磺酰基-L-氨基联苯氯甲基酮 | (S)-N-(4-氯-3-氧代-1-苯基-2-丁基)对甲苯磺酰胺 | N-对-甲苯磺酰基-L-苯基乙基氯甲基酮 | (S)-1-氯-4-苯基-3-甲苯磺酰氨基-2-丁酮 | L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮 | (S)-1-氯-3-甲苯磺酰氨基-4-苯基-2-丁酮
English aliasTPCK | C02088 | NCGC00016020-01 | O-tert-Butylhydroxylamine hydrochloride, >=99% | N-P-tosyl-L-phenylalanyl chloromethyl ketone | NSC 727365 | l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide | NCGC00094419-03 | Tosyl-L-phenylalanylchloromethane |
CAS number402-71-1molecular formulaC17H18ClNO3S
molecular weight351.85 g/molExact mass-
PSA71.600 Ųlogp3.600

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram:
GHS05 , GHS07
Signal word:
Danger
Hazard Statement:
H315: 引起皮肤刺激 H335: 可能引起呼吸道刺激 H318: 造成严重的眼睛损伤
Statement of Preventive Measures:
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱
Personal protective equipment:
dust mask type N95 (US), Eyeshields, Gloves
RTECS:
XT5613500

Production methods and uses

No production method and use information yet

Related

upstream information

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downstream information

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MSDS

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