CMP-唾液酸，钠盐是唾液酸的活性形式。在哺乳动物细胞中，已经证明生物合成含唾液酸的复合碳水化合物是必需的。CMP唾液酸的丢失，单钠盐的产生或CMP唾液酸的反馈抑制剂已导致GLCNE（GNE，UDP-N-乙酰氨基葡糖2-表异构酶/ N-乙酰甘露糖胺激酶）产生克规模的唾液酸。该化合物已显示出通过掩盖结合位点来中和各种毒素的能力。CMP唾液酸单钠盐还通过Galβ1-4GlcNAc基团的唾液酸化作用提供了针对淋球菌的保护作用。通过表面唾液酸转移酶CMP-唾液酸的催化，单钠盐增强了胰岛素的响应性。该化合物还具有调 CMP-sialic acid, Monosodium salt is the active form of sialic acid. In mammalian cells it has been shown to be required for the biosynthesis of sialic acid-containing complex carbohydrates. Loss of CMP sialic acid, Monosodium salt production or the feed back inhibitor of CMP-sialic acid has lead to gram scale production of sialic acid by GLCNE (GNE, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase). The compound has demonstrated the ability to neutralize various toxins through masking binding sites. CMP-sialic acid, Monosodium salt has also provided protection against gonococci by siaylation of Gal beta 1-4GlcNAc group. Catalyzed through a surface sialyl-transferase, CMP-Sialic Acid, Monosodium Salt enhanced the responsiveness of insulin. The compound has also displayed function in blood protein half-life regulation, protection against glycoprotein lysis and cellular adhesion. CMP-Sialic Acid, Monosodium Salt is a substrate of Sialyltransferase.
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CMP-Sialic Acid, Monosodium Salt
CAS number：3063-71-6 molecular formula：C20H30N4O16P·Na
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Specs
| Chinese alias | - | ||
| English alias | D-glycero-beta-D-galacto-2-Nonulopyranosonic acid, 5-(acetylamino)-3,5-dideoxy-, 2-(hydrogen 5'-cytidylate) | CMP-N-acetylneuraminic acid | SCHEMBL23782673 | T8I6M8AXA0 | CMP acetylneuraminic acid | (2R,4S,5R,6R)-5-acetamido-2-[[(2R,3S,4R,5R)-5-(4-amino-2 | ||
| CAS number | 3063-71-6 | molecular formula | C20H30N4O16P·Na |
| molecular weight | 636.43 g/mol | Exact mass | ≥85% |
| PSA | - | logp | - |
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