AM281 是一种选择性 CB1 受体拮抗剂，IC50 为 9.91 nM。AM281 抑制 CB2 受体，IC50 为 13000 nM。 AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM。 Application： AM281 has been used as a cannabinoid 1 receptor antagonist: to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments to study its effect on scopolamine-induced memory deficit using object recognition paradigm to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain
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AM281
Dangerous GoodsCAS number：202463-68-1 molecular formula：C21H19Cl2IN4O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | AM 281 | 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide | ||
| CAS number | 202463-68-1 | molecular formula | C21H19Cl2IN4O2 |
| molecular weight | 557.21 g/mol | Exact mass | - |
| PSA | 59.400 Ų | logp | 5.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H300: 吞咽致命
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
